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20-bp guide RNA sequences were designed using the CRISPR Design Tool ( and expressed along with Cas9 using the plentiCRISPRv2 vector, which was a gift from Feng Zhang (Addgene plasmid # 52961

Two of these, CJC-1295 and ipamorelin*, are peptides that can be administered to help support the production of growth hormone and alleviate various endocrine challenges